Molecular Formula:

Free Base: C4H11NO3 Molecular Weight: 121.1

Hydrochloride: C4H11NO3·HCl Molecular Weight: 157.6

Get A quote and find out about our special offers


Free Base: 77-86-1

Hydrochloride: 1185-53-1

    Synonyms: Tris-[hydroxymethyl]aminomethane; THAM; 2-Amino-2-(hydroxymethyl)- 1,3-propandiol; Tromethamine; Trometamol

    pH of a 0.05 M aqueous Solution:

      Free Base: 10.4
      Hydrochloride: 4.7

    pKa (Tris Base): 8.1 at 25°CpKa (Tris Base): 8.1 at 25°C


    Tris and Tris Hydrochloride have been useful as buffers in a wide variety of biological systems. Uses include pH control in vitro1,2 and in vivo3,4 for body fluids and in buffering systems for electrophoresis applications.2,11 Tris has been used as a starting material for polymers, oxazolones (with carboxylic acids) and oxazolidines (with aldehydes).6 Tris does not precipitate calcium salts and is of value in maintaining solubility of manganese salts.7 It can be used for the direct standardization of a strong acid solution; the equivalence point can be determined either potentiometrically or by use of a suitable indicator such as 3-(4-Dimethylamino-1-naphthylazo)-4-methoxybenzenesulfonic acid (# 0215779250).



      scroll up